Doxofyllin 400mg Tablet

About Doxofyllin 400mg Tablet

Doxofylline 400 mg is an oral bronchodilator belonging to the methylxanthine drug class. It is primarily used for the long-term management and prevention of symptoms associated with chronic respiratory conditions. Core Medical Profile Primary Uses: Indicated for asthma, Chronic Obstructive Pulmonary Disease (COPD), and chronic bronchitis. It helps relieve chest tightness, wheezing, and shortness of breath. Mechanism of Action: It works by inhibiting the phosphodiesterase (PDE) enzyme, which increases levels of cyclic AMP (cAMP). This action relaxes the smooth muscles in the airways, allowing them to widen and improve airflow to the lungs. Differentiating Features: Unlike its predecessor, theophylline, doxofylline has a lower affinity for adenosine receptors, which leads to significantly fewer side effects on the heart and central nervous system. It typically does not require regular blood level monitoring. Usage and Dosage Standard Dose: For adults, the typical dose is 400 mg taken two or three times daily, as prescribed by a physician. Administration: Tablets should be swallowed whole with water and not crushed or chewed. While it can be taken with or without food, taking it after a meal (often in the evening) may help prevent stomach upset. Emergency Note: This is a maintenance medication and cannot be used for sudden asthma attacks. Always keep a fast-acting rescue inhaler for emergencies. Important Safety Information Common Side Effects: These are generally mild and include nausea, vomiting, headache, stomach pain, and insomnia. Serious Warnings: Although rare, it may cause fast or irregular heartbeats and seizures in cases of overdose. Dietary Restrictions: Patients should avoid caffeine (coffee, tea, dark chocolate) and alcohol, as these can increase the risk of side effects. Smoking may also reduce the drug's effectiveness. Contraindications: It is generally avoided in patients with acute myocardial infarction (heart attack), low blood pressure, or those who are breastfeeding.